[Frontiers in Bioscience 10, 12-22, January 1, 2005] 12 MACROPHAGE MIGRATION INHIBITORY FACTOR IN RHEUMATOID ARTHRITIS
نویسندگان
چکیده
1. Abstract 2. Introduction 3. Basic biology of MIF 3.1. MIF: history and discovery 3.2. Structure and biochemical properties 3.3. Enzymatic properties of MIF 4. Expression and function of MIF in immunity and tissues relevant to RA 4.1. Adaptive immunity and T cells 4.2. Innate immunity and monocyte/macrophages 4.3. Other cellular subsets 4.4. MIF and glucocorticoids 5. MIF in rheumatoid arthritis 5.1. MIF in animal models of RA 5.2. MIF and human RA inflammation 5.3. MIF and synovial hypercellularity 5.4. MIF and joint damage 6. Recent advances in MIF biology 6.1. MIF activation of signal transduction pathways 6.2. Identification of a putative MIF receptor 6.3. MIF and p53 6.4. MIF polymorphisms and human disease 7. Perspective 8. Acknowledgement 9. References
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